Long-term potentiation in the hippocampal slice: evidence for stimulated secretion of newly synthesized proteins

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7233208· OSTI ID:5637923

Duffy, C; Teyler, T J; Shashoua, V E

Long-term potentiation of the hippocampal slice preparation results in an increase in the incorporation of labeled valine into the proteins destined for secretion into the extracellular medium. Double-labeling methods established that the increased secretion of the labeled proteins was limited to the potentiated region of a slice; incorporation of labeled valine was increased in the hippocampus if potentiation was through the Schaffer collaterals and in the dentate if potentiation was through the perforant path. Controls for nonspecific stimulation showed no changes. There appears to be a link between long-term potentiation and the metabolic processes that lead to protein synthesis in the hippocampal slice system.

• OSTI ID: 5637923
• Journal Information: Science (Washington, D.C.); (United States), Vol. 212:4499
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
PHYSIOLOGY
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOSYNTHESIS
LABELLED COMPOUNDS
PROTEINS
SAMPLE PREPARATION
SECRETION
VALINE
AMINO ACIDS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
KINETICS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
REACTION KINETICS
SYNTHESIS
551001* - Physiological Systems- Tracer Techniques
550201 - Biochemistry- Tracer Techniques