Inspiratory flow and intrapulmonary gas distribution

Rehder, K; Knopp, T J; Brusasco, V; Didier, E P

Title: Inspiratory flow and intrapulmonary gas distribution

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Abstract

The effect of flow of inspired gas on intrapulmonary gas distribution was examined by analysis of regional pulmonary /sup 133/Xe clearances and of total pulmonary /sup 133/Xe clearance measured at the mouth after equilibration of the lungs with /sup 133/Xe. Five awake healthy volunteers (24 to 40 yr of age) and another 5 healthy, anesthetized-paralyzed volunteers (26 to 28 yr of age) were studied while they were in the right lateral decubitus position. The awake subjects were studied at 3 inspiratory flows (0.4, 0.7, and 1.0 L/s) and the anesthetized-paralyzed subjects at 4 inspiratory flows (0.2, 0.5, 1.1, and 1.6 L/s). Interregional differences in /sup 133/Xe clearances along the vertical axis were significantly less during anesthesia-paralysis and mechanical ventilation than during spontaneous breathing in the awake state. No differences in the regional or total pulmonary /sup 133/Xe clearances were detected at these different flows in either of the two states, i.e., the difference between the awake and anesthetized-paralyzed states persisted.

Authors:: Rehder, K; Knopp, T J; Brusasco, V; Didier, E P

Publication Date:: Thu Jan 01 00:00:00 EST 1981

Research Org.:: Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, MN

OSTI Identifier:: 5635378

Resource Type:: Journal Article

Journal Name:: Am. Rev. Respir. Dis.; (United States)

Additional Journal Information:: Journal Volume: 124:4

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; FLOW RATE; BIOLOGICAL EFFECTS; LUNGS; RADIONUCLIDE KINETICS; XENON 133; LUNG CLEARANCE; TISSUE DISTRIBUTION; ANESTHESIA; MAN; RESPIRATION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; EVEN-ODD NUCLEI; EXCRETION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; NUCLEI; ORGANS; PRIMATES; RADIOISOTOPES; RESPIRATORY SYSTEM; VERTEBRATES; XENON ISOTOPES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

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                    Rehder, K, Knopp, T J, Brusasco, V, and Didier, E P. Inspiratory flow and intrapulmonary gas distribution.  United States: N. p., 1981. 
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                    Rehder, K, Knopp, T J, Brusasco, V, & Didier, E P. Inspiratory flow and intrapulmonary gas distribution.  United States.

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                    Rehder, K, Knopp, T J, Brusasco, V, and Didier, E P. 1981.  
        "Inspiratory flow and intrapulmonary gas distribution".  United States.

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@article{osti_5635378,

  title        = {Inspiratory flow and intrapulmonary gas distribution},

  author       = {Rehder, K and Knopp, T J and Brusasco, V and Didier, E P},

  abstractNote = {The effect of flow of inspired gas on intrapulmonary gas distribution was examined by analysis of regional pulmonary /sup 133/Xe clearances and of total pulmonary /sup 133/Xe clearance measured at the mouth after equilibration of the lungs with /sup 133/Xe. Five awake healthy volunteers (24 to 40 yr of age) and another 5 healthy, anesthetized-paralyzed volunteers (26 to 28 yr of age) were studied while they were in the right lateral decubitus position. The awake subjects were studied at 3 inspiratory flows (0.4, 0.7, and 1.0 L/s) and the anesthetized-paralyzed subjects at 4 inspiratory flows (0.2, 0.5, 1.1, and 1.6 L/s). Interregional differences in /sup 133/Xe clearances along the vertical axis were significantly less during anesthesia-paralysis and mechanical ventilation than during spontaneous breathing in the awake state. No differences in the regional or total pulmonary /sup 133/Xe clearances were detected at these different flows in either of the two states, i.e., the difference between the awake and anesthetized-paralyzed states persisted.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5635378},
  journal      = {Am. Rev. Respir. Dis.; (United States)},
number       = ,

  volume       = 124:4,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 1981},

  month        = {Thu Jan 01 00:00:00 EST 1981}

}

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