Synthesis, NMR characterization, and a simple application of lithium borotritide
- Lawrence Berkeley National Lab., CA (United States)
- Sandoz Pharma Ltd., Basle (Switzerland); and others
LiBH{sub 4} is a powerful and selective reagent for regiospecific reduction reactions. A simple synthesis of LiB{sup 3}H{sub 4} at near theoretical specific radioactivity is reported. The authors have treated Li{sup 3}H synthesized from tritium gas ({sup 3}H{sub 2}, {approximately}98%) with BBr{sub 3} to produce LiB{sup 3}H{sub 4} (specific activity = 4120 GBq/mmol = 110 Ci/mmol. The maximum theoretical specific activity of LiB{sup 3}H{sub 4} is 4252 GBq/mmol = 115.04 Ci/mmol; 1 matom of {sup 3}H = 1063 GBq = 28.76 Ci.) The tritium labeling performance of the reagent was tested by an exemplary reduction of 2-naphthaldehyde to 2-naphthalenemethanol. LiB{sup 3}H{sub 4} and the reduction products were characterized by a combination of {sup 1}H, {sup 3}H, and {sup 11}B NMR techniques, as appropriate. 35 refs., 1 fig.
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 563468
- Journal Information:
- Journal of Organic Chemistry, Vol. 61, Issue 25; Other Information: PBD: 13 Dec 1996
- Country of Publication:
- United States
- Language:
- English
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