skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats

Abstract

2,3-Dichloropropene (DCP) is an intermediate used in the manufacture of carbamate herbicides and there is potential for human exposure during the manufacturing process. DCP is a known mutagen in bacteria systems and some structural analogs of DCP are carcinogenic. Since little is known about the disposition of DCP in animals after inhalation, studies were conducted in male Fischer-344 rats to determine the effect of vapor concentration on absorption and excretion. Uptake and elimination of /sup 14/C was studied in rats after nose-only inhalation of 17, 240, or 1650 nmol of (/sup 14/C)DCP vapor/liter of air (0.4, 6, or 40 ppm, respectively, at 760 mm and 25 degrees C) for 6 hr. The percentage of inhaled DCP absorbed averaged 38% and was not statistically different at any vapor concentration, although minute volume was lower during exposure to 1650 nmol/liter. Urine, feces, and expired air were collected from rats for 65 hr after exposure. Rats were sacrificed and tissues, carcass, excreta, and expired air were analyzed for /sup 14/C. Routes of /sup 14/C excretion were independent of vapor concentration, with 50% of the /sup 14/C excreted in urine, 13% in feces, approximately 7% as CO/sub 2/, and less than 1% as DCPmore » in expired air. Rates of /sup 14/C excretion were also independent of vapor concentration, with the half-times averaging 9.9 hr (urine), 13.6 hr (feces), and 0.9 hr (/sup 14/CO/sub 2/). Sixty hours after inhalation, 29% of the initial body burden of /sup 14/C remained in the carcass. Most was associated with the pelt, but some /sup 14/C was found in all tissues. Respiratory tract, GI tract, liver, and kidney were tissues with the highest /sup 14/C contents. The results indicate that DCP metabolism and excretion rates are relatively constant throughout the vapor concentration range studied.« less

Authors:
; ; ; ; ; ;
Publication Date:
OSTI Identifier:
5631820
Resource Type:
Journal Article
Journal Name:
Fundam. Appl. Toxicol.; (United States)
Additional Journal Information:
Journal Volume: 5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; CHLORINATED ALIPHATIC HYDROCARBONS; METABOLISM; TISSUE DISTRIBUTION; ABSORPTION; BIOLOGICAL HALF-LIFE; BODY BURDEN; CARBON 14 COMPOUNDS; DOSE-RESPONSE RELATIONSHIPS; EXCRETION; FECES; GASTROINTESTINAL TRACT; HERBICIDES; INHALATION; KIDNEYS; LIVER; RATS; RESPIRATORY SYSTEM; TRACER TECHNIQUES; URINE; VAPORS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CLEARANCE; DIGESTIVE SYSTEM; DISTRIBUTION; FLUIDS; GASES; GLANDS; HALOGENATED ALIPHATIC HYDROCARBONS; INTAKE; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANS; PESTICIDES; RODENTS; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Dutcher, J S, Medinsky, M A, Bond, J A, Cheng, Y S, Snipes, M B, Henderson, R F, and Birnbaum, L S. Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats. United States: N. p., 1985. Web. doi:10.1016/0272-0590(85)90182-4.
Dutcher, J S, Medinsky, M A, Bond, J A, Cheng, Y S, Snipes, M B, Henderson, R F, & Birnbaum, L S. Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats. United States. https://doi.org/10.1016/0272-0590(85)90182-4
Dutcher, J S, Medinsky, M A, Bond, J A, Cheng, Y S, Snipes, M B, Henderson, R F, and Birnbaum, L S. 1985. "Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats". United States. https://doi.org/10.1016/0272-0590(85)90182-4.
@article{osti_5631820,
title = {Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats},
author = {Dutcher, J S and Medinsky, M A and Bond, J A and Cheng, Y S and Snipes, M B and Henderson, R F and Birnbaum, L S},
abstractNote = {2,3-Dichloropropene (DCP) is an intermediate used in the manufacture of carbamate herbicides and there is potential for human exposure during the manufacturing process. DCP is a known mutagen in bacteria systems and some structural analogs of DCP are carcinogenic. Since little is known about the disposition of DCP in animals after inhalation, studies were conducted in male Fischer-344 rats to determine the effect of vapor concentration on absorption and excretion. Uptake and elimination of /sup 14/C was studied in rats after nose-only inhalation of 17, 240, or 1650 nmol of (/sup 14/C)DCP vapor/liter of air (0.4, 6, or 40 ppm, respectively, at 760 mm and 25 degrees C) for 6 hr. The percentage of inhaled DCP absorbed averaged 38% and was not statistically different at any vapor concentration, although minute volume was lower during exposure to 1650 nmol/liter. Urine, feces, and expired air were collected from rats for 65 hr after exposure. Rats were sacrificed and tissues, carcass, excreta, and expired air were analyzed for /sup 14/C. Routes of /sup 14/C excretion were independent of vapor concentration, with 50% of the /sup 14/C excreted in urine, 13% in feces, approximately 7% as CO/sub 2/, and less than 1% as DCP in expired air. Rates of /sup 14/C excretion were also independent of vapor concentration, with the half-times averaging 9.9 hr (urine), 13.6 hr (feces), and 0.9 hr (/sup 14/CO/sub 2/). Sixty hours after inhalation, 29% of the initial body burden of /sup 14/C remained in the carcass. Most was associated with the pelt, but some /sup 14/C was found in all tissues. Respiratory tract, GI tract, liver, and kidney were tissues with the highest /sup 14/C contents. The results indicate that DCP metabolism and excretion rates are relatively constant throughout the vapor concentration range studied.},
doi = {10.1016/0272-0590(85)90182-4},
url = {https://www.osti.gov/biblio/5631820}, journal = {Fundam. Appl. Toxicol.; (United States)},
number = ,
volume = 5,
place = {United States},
year = {Tue Oct 01 00:00:00 EDT 1985},
month = {Tue Oct 01 00:00:00 EDT 1985}
}