Response of human malignant melanoma xenografts to hyperthermia: effect of vascular occlusion

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90193-0· OSTI ID:5628784

Rofstad, E K; Brustad, T

Two human malignant melanomas from two patients, grown subcutaneously in the leg of athymic nude mice, were exposed to hyperthermia (42.5/sup o/C) for varying times. Single cell survival was assayed in vitro in soft agar. The sensitivity to heat of the tumor cells was considerably enhanced when the blood supply to the tumors was occluded 15 min before and during treatment. The D/sub 0/-values of the survival curves were 86 min (unclamped) and 13 min (clamped) for E.E. melanoma and 25 min (unclamped) and 11 min (clamped) for V.N. melanoma.

• Research Organization: Norwegian Radium Hospital, Oslo
• OSTI ID: 5628784
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
MELANOMAS
RADIOTHERAPY
ANIMAL CELLS
MICE
PATIENTS
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
TUMOR CELLS
ANIMALS
BODY TEMPERATURE
DISEASES
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560121 - Radiation Effects on Cells- External Source- (-1987)
550603 - Medicine- External Radiation in Therapy- (1980-)