Osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex

Journal Article · Thu Oct 01 00:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:5628218

Packard, A B; Treves, S T; O'Brien, G M; Lim, K S

A new osmium-191/iridium-191m (/sup 191/Os//sup 191/mIr) radionuclide generator has been developed that offers high /sup 191/mIr yield (greater than 20%/ml) and low /sup 191/Os breakthrough (less than 5 X 10(-4)%/ml) when eluted with a solution of 0.001 M oxalic acid and 0.9% (normal) saline. This is the first /sup 191/Os//sup 191/mIr generator that combines the advantages of high /sup 191/mIr yield, extremely low /sup 191/Os breakthrough, and an eluate that does not require buffering prior to injection. These improvements in performance were accomplished through use of the chelate transdioxobisoxalatoosmate(VI) as the parent complex on the generator. The clinical result of the combination of higher yield and lower breakthrough is a 100-fold decrease in the estimated patient radiation dose compared with the same study performed with technetium-99m (/sup 99m/Tc), and the injectable eluate makes the generator easier to use. Acute and subacute toxicity studies performed on this generator eluate have shown no adverse effects attributable to the eluate.

• Research Organization: Medical School, Boston, MA
• OSTI ID: 5628218
• Journal Information: J. Nucl. Med.; (United States), Vol. 28:10
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
07 ISOTOPES AND RADIATION SOURCES
RADIOISOTOPE GENERATORS
DESIGN
IRIDIUM 191
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
OSMIUM 191
OXALATES
RADIATION DOSES
TECHNETIUM 99
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACID SALTS
DAYS LIVING RADIOISOTOPES
DOSES
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OSMIUM ISOTOPES
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
070201 - Radiation Sources- Design
Fabrication & Operation