DNA synthesis in mouse brown adipose tissue is under. beta. -adrenergic control

Journal Article · Wed Feb 01 00:00:00 EST 1989 · Experimental Cell Research; (United States)

DOI:https://doi.org/10.1016/0014-4827(89)90086-4· OSTI ID:5623327

Rehnmark, S; Nedergaard, J ^[1]

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1. Univ. of Stockholm (Sweden)

The rate of DNA synthesis in mouse brown adipose tissue was followed with injections of ({sup 3}H)thymidine. Cold exposure led to a large increase in the rate of ({sup 3}H)thymidine incorporation, reaching a maximum after 8 days, after which the activity abruptly ceased. A series of norepinephrine injections was in itself able to increase ({sup 3}H)thymidine incorporation. When norepinephrine was injected in combination with the {alpha}-adrenergic antagonist phentolamine or with the {beta}-adrenergic antagonist propranolol, the stimulation was fully blocked by propranolol. It is suggested that stimulation of DNA synthesis in brown adipose tissue is a {beta}-adrenergically mediated process and that the tissue is an interesting model for studies of physiological control of DNA synthesis.

• OSTI ID: 5623327
• Journal Information: Experimental Cell Research; (United States), Vol. 180:2; ISSN 0014-4827
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
CELL PROLIFERATION
DNA REPLICATION
PHYSIOLOGY
TRITIUM COMPOUNDS
UPTAKE
NORADRENALINE
THYMIDINE
ADRENAL HORMONES
ANIMAL TISSUES
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CONNECTIVE TISSUE
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN COMPOUNDS
NEUROREGULATORS
NUCLEIC ACID REPLICATION
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
SYMPATHOMIMETICS
TISSUES
550301* - Cytology- Tracer Techniques