Effects of endotoxin on mammary secretion of lactating cows. [Escherichia coli]
The objectives were to describe the magnitude and time course of changes in milk pH, Na, K, lactose, and somatic cells and to determine if paracellular pathways were altered after infusion of Escherichia coli endotoxin (serotype 0128:AB12) to produce inflammation in one-half of the udder of the goat. Intramammary infusion of endotoxin increased pH, number of somatic cells, and Na and decreased K and lactose in milk. Sodium and number of somatic cells were increased by as little as .1..mu..g of endotoxin; .25 ..mu..g produced changes in most of the other parameters; maximal effect was elicited by 1..mu..g of endotoxin. The gland response peaked from 5 to 7 h after infusion of endotoxin with an increase in milk cellularity as the only significant effect noted in the control gland. Infusion of (/sup 14/C)lactose into the gland and (/sup 99m/Tc)albumin into the blood demonstrated that large molecules were more able to cross into and out of udder halves after endotoxin treatment. It is suggested that ion interchange rather than bulk flow across paracellular paths is responsible for changes. In addition, endotoxin appeared to reduce lactose secretion and synthesis.
- Research Organization:
- New York State College of Veterinary Medicine, Ithaca
- OSTI ID:
- 5618106
- Journal Information:
- J. Dairy Sci.; (United States), Vol. 69:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Measures of de novo synthesis of milk components from propionate in lactating goats
PERMEABILITY OF THE MAMMARY GLAND TO SODIUM-24, POTASSIUM-42, CHLORINE-36 AND IODINE-131
Related Subjects
ENDOTOXINS
BIOLOGICAL EFFECTS
MAMMARY GLANDS
BIOLOGICAL FUNCTIONS
INFLAMMATION
MILK
CHEMICAL COMPOSITION
ALBUMINS
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
ESCHERICHIA COLI
GOATS
ISOMERIC NUCLEI
LACTOSE
PH VALUE
SODIUM
TECHNETIUM 99
TRACER TECHNIQUES
ALKALI METALS
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOHYDRATES
DISACCHARIDES
DOMESTIC ANIMALS
ELEMENTS
FOOD
FUNCTIONS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIOISOTOPES
RUMINANTS
SACCHARIDES
SYMPTOMS
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
553001* - Agriculture & Food Technology- Tracer Techniques- (-1987)