Methylmercury toxicity in spontaneously hypertensive rats (SHR)
Information is scant on both environmental and individual factors as potentiators of methylmercury (MeHg) toxicity in human beings and other animal species. Hypertension is quite common among the inhabitants of MeHg-polluted areas. It is of special interest to learn what is the health consequence among the hypertensives who have been exposed to MeHg for a prolonged period of time. This study was designed to delineate the toxicity of MeHg in animals having high blood pressure using the laboratory model of spontaneously hypertensive rats (SHR). This paper presents the mortality as well as distribution of mercury in the tissues of SHR and control rats treated orally with methylmercury chloride for 10 consecutive days.
- Research Organization:
- National Institute for Minamata Disease, Minamata City, Japan
- OSTI ID:
- 5616879
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 36:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HYPERTENSION
BIOLOGICAL EFFECTS
METHYLMERCURY
TISSUE DISTRIBUTION
MERCURY CHLORIDES
MORTALITY
ORAL ADMINISTRATION
RATS
ANIMALS
CARDIOVASCULAR DISEASES
CHLORIDES
CHLORINE COMPOUNDS
DISEASES
DISTRIBUTION
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)