Strontium-89 therapy for the pain of osseous metastases
A Phase I and II study has been conducted of the safety and efficacy of /sup 89/Sr (injected i.v. as the chloride) to alleviate bone pain due to osseous metastatic disease. Potential attendant hematologic toxicity was also examined. Thirty-eight patients with pain due to osseous metastases requiring regular narcotic more than twice a day, documented by an abnormal bone scan and radiography, received 45 doses of /sup 89/Sr after informed consent. The performance status (Karnofsky scale) ranged from 20-80%. One patient had complete pain relief while 22 other doses yielded at least a 25% reduction in narcotic requirement lasting at least 1 mo and/or 20% improvement in Karnofsky scale rating. Two patients had marked to complete relief in tumor sites which were not fractured, with no change in fracture pain. Twenty-two did not respond. Response was independent of narcotic requirements, tumor type, or Karnofsky status. No hematologic toxicity occurred. Strontium-89 may be useful as adjuvant therapy for diffuse bone pain, but a double-blind study comparing it to other nonnarcotic modalities is required.
- Research Organization:
- Univ. of Cincinnati Medical Center, OH
- OSTI ID:
- 5614612
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:4
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
METASTASES
RADIOTHERAPY
SIDE EFFECTS
PAIN
PATIENTS
SKELETON
STRONTIUM 89
ALKALINE EARTH ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
STRONTIUM ISOTOPES
SYMPTOMS
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man