Prevention of cardiac damage induced by formyl-leurosine, a potent cytostatic agent, by radio-detoxified endotoxin (Tolerin) in dogs

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Immunopharmacology; (United States)

DOI:https://doi.org/10.1016/0162-3109(84)90052-3· OSTI ID:5613789

Bertok, L; Juhasz-Nagy, A; Sotonyi, P

Radio-detoxified endotoxin (Tolerin), produced by /sup 60/Co-gamma irradiation of Escherichia coli 089 endotoxin, can protect dogs against the acute cardiotoxic side-effects of formyl-leurosine, a semi-synthetic Vinca derivative with promising antineoplastic potency. Formyl-leurosine induces a rapid decrease in arterial blood pressure and diminishes the contractile force of the myocardium in the anaesthetized dog. These responses indicate a direct pharmacologic relaxant effect of the drug on the heart and vasculature smooth muscle. The early cardiovascular depression is of short duration and is unaffected by Tolerin. Tolerin can prevent, however, the secondary, more dangerous phase of circulatory depression that is associated with the severe cardiotoxic manifestations of the drug, as demonstrated by hemodynamic and morphologic (light and electronmicroscopic) patterns.

• Research Organization: National Research Inst. for Radiobiology and Radiohygiene, Budapest, Hungary
• OSTI ID: 5613789
• Journal Information: Immunopharmacology; (United States), Vol. 8:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
SIDE EFFECTS
ENDOTOXINS
DETOXIFICATION
LETHAL IRRADIATION
ALKALOIDS
BLOOD PRESSURE
CHEMOTHERAPY
COBALT 60
DOGS
ESCHERICHIA COLI
MYOCARDIUM
PHARMACOLOGY
RESPONSE MODIFYING FACTORS
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COBALT ISOTOPES
DRUGS
HEART
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
THERAPY
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560134* - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)