Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography
The cerebral metabolic rate for glucose was studied in ten men (mean age = 26 years) with well-documented histories of infantile autism and in 15 age-matched normal male controls using positron emission tomography and (F-18) 2-fluoro-2-deoxy-D-glucose. Positron emission tomography was completed during rest, with reduced visual and auditory stimulation. While the autistic group as a whole showed significantly elevated glucose utilization in widespread regions of the brain, there was considerable overlap between the two groups. No brain region showed a reduced metabolic rate in the autistic group. Significantly more autistic, as compared with control, subjects showed extreme relative metabolic rates (ratios of regional metabolic rates to whole brain rates and asymmetries) in one or more brain regions.
- Research Organization:
- National Institute of Mental Health, Bethesda, MD
- OSTI ID:
- 5612899
- Journal Information:
- Arch. Gen. Psychiatr.; (United States), Vol. 42:5
- Country of Publication:
- United States
- Language:
- English
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BRAIN
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
METABOLIC DISEASES
ALDEHYDES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
HEXOSES
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
SACCHARIDES
TOMOGRAPHY
550501* - Metabolism- Tracer Techniques