Cyclooxygenase blockade (COB) attenuates ethanol-induced pulmonary vasoconstriction in perfused rat lungs

Conference · Mon Feb 26 00:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5610806

Drummond, W H; Lyles, D ^[1]

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1. Univ. of Florida, Gainesville (United States)

Ethanol causes pulmonary vasoconstriction and vascular leak by obscure mechanisms. In lambs, COB with indomethacin (Indo) or meclofenamate (Meclo) block ethanol's circulatory effects. To test for these effects in rats, in-situ, ventilated, Krebs-Henselheit perfused (constant flow) lungs were studied in 6 groups: ethanol (ETOH) and perfusate controls; ETOH/Meclo, 0.5 and 1 mg/kg, IV; ETOH/Indo, 0.5 and 1 mg/kg, IV, given 30 minutes before study. They measured mean pulmonary arterial pressure (PAP), peak inspiratory pressure (PIP) and edema, indexed by reservoir weight change (RW), then by tracheal froth ( death'). ETOH doses (0.5, 1.3 and 2.2gm) were infused into the perfusate (60 ml). Data were analyzed by ANOVA and X{sup 2}; n = 9 in each group. PAP differed by treatment, by drug/dose, and by dose/treatment interactions; PIP, RW change, and death' were attenuated. Data show that COB lessens the vascular and edema effects of moderate dose ETOH, which larger ETOH doses override.

• OSTI ID: 5610806
• Report Number(s): CONF-9004153-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 4:3; Conference: 74. annual meeting of the Federation of American Societies for Experimental Biology, Washington, DC (United States), 1-5 Apr 1990; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
TOXICITY
LUNGS
VASOCONSTRICTION
OXYGENASES
BIOCHEMICAL REACTION KINETICS
DRUGS
PERFUSED ORGANS
RATS
ALCOHOLS
ANIMALS
BODY
ENZYMES
HYDROXY COMPOUNDS
KINETICS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology