Cholestyramine-enhanced fecal elimination of carbon-14 in rats after administration of ammonium (/sup 14/C)perfluorooctanoate or potassium (/sup 14/C)perfluorooctanesulfonate

Journal Article · Sat Dec 01 00:00:00 EST 1984 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(84)90235-5· OSTI ID:5606988

Johnson, J D; Gibson, S J; Ober, R E

After a single intravenous dose of ammonium (/sup 14/C)perfluorooctanoate (( /sup 14/C)PFO, 13.3 mg/kg) or of potassium (/sup 14/C)perfluorooctanesulfonate (( /sup 14/C)PFOS, 3.4 mg/kg) to rats, cholestyramine fed daily as a 4% mixture in feed was shown to increase the total carbon-14 eliminated via feces and to decrease liver concentration of carbon-14. Rats were fed cholestyramine in feed for 14 days after administration of (/sup 14/C)PFO and for 21 days after administration of (/sup 14/C)PFOS. Control rats were administered radiolabeled fluorochemical but were not treated with cholestyramine. Cholestyramine treatment increased mean cumulative carbon-14 elimination in feces by 9.8-fold for rats administered (/sup 14/C)PFO and by 9.5-fold for rats administered (/sup 14/C)PFOS. After (/sup 14/C)PFO, a mean of 4% of the dose of carbon-14 was in liver of cholestyramine-treated rats at 14 days versus 7.6% in control rats; after (/sup 14/C)PFOS, 11.3% of the dose was in liver at 21 days versus 40.3% in control rats. After administration of either radiolabeled compound, plasma and red blood cell carbon-14 concentrations, which were relatively lower than liver concentrations, were also significantly reduced by cholestyramine treatment.

• Research Organization: Riker Laboratories, Inc., St. Paul, MN
• OSTI ID: 5606988
• Journal Information: Fundam. Appl. Toxicol.; (United States), Vol. 4:6
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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CARBON 14
EXCRETION
AMMONIUM COMPLEXES
FECES
LABELLED COMPOUNDS
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BODY
CARBON ISOTOPES
CLEARANCE
COMPLEXES
DIGESTIVE SYSTEM
EVEN-EVEN NUCLEI
GLANDS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
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NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
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RODENTS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
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