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Title: Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

Abstract

The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected in DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.

Authors:
; ; ;  [1]
  1. National Cancer Institute, Frederick, MD (USA)
Publication Date:
OSTI Identifier:
5606497
Resource Type:
Journal Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America; (USA)
Additional Journal Information:
Journal Volume: 85:20; Journal ID: ISSN 0027-8424
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DNA; HYBRIDIZATION; NERVOUS SYSTEM DISEASES; GENETICS; ONCOGENES; ANEUPLOIDY; ADULTS; AUTORADIOGRAPHY; BRAIN; DOWNS SYNDROME; FIBROBLASTS; HEREDITARY DISEASES; HUMAN CHROMOSOME 21; KARYOTYPE; PATIENTS; RFLPS; AGE GROUPS; ANIMAL CELLS; BIOLOGY; BODY; CENTRAL NERVOUS SYSTEM; CHROMOSOMES; CONGENITAL MALFORMATIONS; CONNECTIVE TISSUE CELLS; DISEASES; GENES; MALFORMATIONS; NERVOUS SYSTEM; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PLOIDY; SOMATIC CELLS; 550401* - Genetics- Tracer Techniques

Citation Formats

Sacchi, N, Nalbantoglu, J, Sergovich, F R, and Papas, T S. Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease. United States: N. p., 1988. Web. doi:10.1073/pnas.85.20.7675.
Sacchi, N, Nalbantoglu, J, Sergovich, F R, & Papas, T S. Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease. United States. https://doi.org/10.1073/pnas.85.20.7675
Sacchi, N, Nalbantoglu, J, Sergovich, F R, and Papas, T S. 1988. "Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease". United States. https://doi.org/10.1073/pnas.85.20.7675.
@article{osti_5606497,
title = {Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease},
author = {Sacchi, N and Nalbantoglu, J and Sergovich, F R and Papas, T S},
abstractNote = {The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected in DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.},
doi = {10.1073/pnas.85.20.7675},
url = {https://www.osti.gov/biblio/5606497}, journal = {Proceedings of the National Academy of Sciences of the United States of America; (USA)},
issn = {0027-8424},
number = ,
volume = 85:20,
place = {United States},
year = {Sat Oct 01 00:00:00 EDT 1988},
month = {Sat Oct 01 00:00:00 EDT 1988}
}