Noncontrast and contrast enhanced MR imaging in the evaluation of partial ureteral obstruction: An experimental study in the micropig

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Investigative Radiology; (USA)

DOI:https://doi.org/10.1097/00004424-198907000-00007· OSTI ID:5604671

Thurnher, S; Tzika, A A; Hricak, H; Mattei, P; Aboseif, S; Engelstad, B; Price, D C ^[1]

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1. Univ. of California School of Medicine, San Francisco (USA)

Twelve Yucatan micropigs (3 controls; 3 sham-operated; 6 with unilateral obstruction) were studied to assess the value of noncontrast and contrast-enhanced (Gadolinium-DTPA) magnetic resonance (MR) imaging in the evaluation of partial ureteral obstruction. MR findings were correlated with findings of quantitative (Tc-99m-DMSA) scintigraphy, and histology. On noncontrast T1-weighted images, the normal porcine kidney demonstrated good corticomedullary contrast (CMC = 16.8% +/- 5.0). Five minutes after administration of Gd-DTPA, there was enhancement of the renal cortex (+24.4%) and medulla (+46.2%), and CMC was no longer discernible. Enhancement of the urine within the collecting system (+119.1%) was also observed. The obstructed kidneys demonstrated marked thinning of the renal parenchyma and decreased signal intensity on noncontrast T1- and T2-weighted images (P less than 0.01). Urine in the dilated collecting system did not differ significantly from urine in controls except in the three animals with urinary tract infection (P less than 0.05). Five minutes following injection of Gd-DTPA, there was enhancement of the renal parenchyma in all kidneys. Excretion was seen in three pigs and no excretion in two. Thus, useful information can be obtained in partial ureteral obstruction from both pre-contrast and Gd-DTPA-enhanced MR images of the kidney.

• OSTI ID: 5604671
• Journal Information: Investigative Radiology; (USA), Vol. 24:7; ISSN 0020-9996
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
KIDNEYS
IMAGE PROCESSING
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
CONTRAST MEDIA
DTPA
ISOMERIC NUCLEI
MAGNETIC RESONANCE
MINIATURE SWINE
NMR IMAGING
ORGANOMETALLIC COMPOUNDS
SCINTISCANNING
TECHNETIUM 99
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESONANCE
SWINE
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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