Tyrosine aminotransferase activity in the benzene intoxicated rat

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01609700· OSTI ID:5603498

Bong, M; Michalska, A; Laskowska-Klita, T; Szymczyk, T

The toxic effect of hydrocarbon solvents on hepatic metabolism manifests itself by changes in the enzymatic pattern of blood serum. Changes in the activity of phosphatases as well as leucine aminopeptidase, glutamine aminotransferase, sorbitol dehydrogenase and ..gamma..-glutamyltransferase were observed in rats intoxicated with different fractions of benzene. Therefore it seemed reasonable to investigate the effect of benzene fraction of petroleum on cellular metabolism. The results of the present work concern the activity of tyrosine aminotransferase, the enzyme involved in catabolism of aromatic amino acid which is known to be under both hormonal and stress dependent control. Changes in tyrosine aminotransferase activity effect the level of tyrosine oxidation as well as the metabolic conversion of this amino acid into tyramine, tyroxin, adrenaline and noradrenaline.

• Research Organization: Warsaw Medical School, Poland
• OSTI ID: 5603498
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 34:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINOTRANSFERASES
ENZYME ACTIVITY
BENZENE
BIOLOGICAL EFFECTS
PETROLEUM
RATS
TYROSINE
AMINO ACIDS
ANIMALS
AROMATICS
CARBOXYLIC ACIDS
ENERGY SOURCES
ENZYMES
FOSSIL FUELS
FUELS
HYDROCARBONS
HYDROXY ACIDS
MAMMALS
NITROGEN TRANSFERASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
TRANSFERASES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)