Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group

Journal Article · Sat Jun 01 00:00:00 EDT 1991 · Cancer Research; (USA)

OSTI ID:5602079

Tucker, M A; Jones, P H; Boice, Jr, J D; Robison, L L; Stone, B J; Stovall, M; Jenkin, R D; Lubin, J H; Baum, E S; Siegel, S E ^[1]

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1. National Cancer Institute, Bethesda, MD (USA)

We estimated the risk of thyroid cancer among 9170 patients who had survived 2 or more years after the diagnosis of a cancer in childhood. As compared with the general population, patients had a 53-fold increased risk (95% confidence interval, 34-80). Risk increased significantly with time since treatment for the initial cancer (P = 0.03). Detailed treatment data were obtained for 23 cases and 89 matched controls from the childhood cancer cohort. Sixty-eight % of the thyroid cancers arose within the field of radiation. Radiation doses to the thyroid of greater than 200 cGy were associated with a 13-fold increased risk (95% confidence interval, 1.7-104). The risk of thyroid cancer rose with increasing dose (P less than 0.001), but this was derived almost entirely from the increase from less than 200 to greater than 200 cGy. The risk of thyroid cancer did not decrease, however, at radiation doses as high as 6000 cGy.

• OSTI ID: 5602079
• Journal Information: Cancer Research; (USA), Vol. 51:11; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
THYROID
DELAYED RADIATION EFFECTS
PATIENTS
RADIATION DOSES
RISK ASSESSMENT
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOSES
ENDOCRINE GLANDS
GLANDS
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)