Urinary concentration of solvents as a biological indicator of exposure: proposal for the biological equivalent exposure limit for nine solvents
Organic solvents are generally volatile substances that are absorbed mainly through the lungs; they are eliminated chiefly through the lungs and kidneys. In urine they are present as metabolites and, in very little part, as parent compound. The urinary concentration of solvent (Cu) can be used for the biological monitoring of exposed subjects to evaluate their exposure and correlate with the Threshold Limit Value (TLV) during the working day. The authors report some results obtained with workers occupationally exposed to solvents. The results concern the correlation between urinary concentration (Cu, micrograms/L) vs. average environmental concentration (Ci, mg/m3) measured in the breathing zone. For each solvent studied (acetone, 2-cyclohexane, 1,2-dichloropropane, n-hexane, methyl ethyl ketone, perchloroethylene, styrene, toluene, 1,1,1-trichloroethane) the authors propose a Biological Equivalent Exposure Limit (BEEL) corresponding to the environmental TLV.
- Research Organization:
- Universita di Pavia, Italy
- OSTI ID:
- 5601034
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Vol. 48:9
- Country of Publication:
- United States
- Language:
- English
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ORGANIC SOLVENTS
MAXIMUM PERMISSIBLE EXPOSURE
METABOLISM
ACETONE
AIR POLLUTION
BIOLOGICAL INDICATORS
CHLORINATED ALIPHATIC HYDROCARBONS
CYCLOHEXANE
HEXANE
KETONES
KIDNEYS
LUNGS
STYRENE
TOLUENE
URINE
ALKANES
ALKYLATED AROMATICS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CYCLOALKANES
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
POLLUTION
RESPIRATORY SYSTEM
SAFETY STANDARDS
SOLVENTS
STANDARDS
WASTES
560300* - Chemicals Metabolism & Toxicology