Effect of indomethacin on alcohol-induced morphological anomalies in mice

Journal Article · Mon Jul 20 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90161-5· OSTI ID:5600943

Randall, C L; Anton, R F; Becker, H C

The purpose of the present study was 1) to examine the effect of indomethacin (INDO), a prostaglandin synthesis inhibitor, on alcohol-induced growth and morphological impairment in C57BL/6J mice (Study 1) and 2) to determine if INDO crosses the placenta (Study 2). On day 10 of gestation, mice were injected (s.c.) acutely with either 0, 5, 10, or 20 mg/kg INDO, followed one hour later by alcohol (5.8 g/kg orally) or isocaloric sucrose. Fetuses were removed on day 19 of pregnancy, weighed, and examined for anomalous development. As expected, Study 1 demonstrated that maternal alcohol treatment decreased fetal weight and increased the number of fetuses with birth defects. INDO alone decreased fetal weight but did not affect morphologic development. More importantly, INDO antagonized alcohol-induced birth defects, but only at the highest dose. The results of Study 2 suggest that the relative ineffectiveness of INDO may be related to its inability to readily cross the placenta. Since high doses of INDO also caused maternal toxicity, the usefulness of this compound in future studies of this type was questioned. 22 references, 4 tables.

• Research Organization: Medical Univ. of South Carolina, Charleston
• OSTI ID: 5600943
• Journal Information: Life Sci.; (United States), Vol. 41:3
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIPYRETICS
BIOLOGICAL EFFECTS
MEMBRANE TRANSPORT
ETHANOL
TERATOGENESIS
TOXICITY
FETUSES
MORPHOLOGICAL CHANGES
EXPERIMENTAL DATA
MICE
PLACENTA
PREGNANCY
ALCOHOLS
ANIMALS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
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DRUGS
FETAL MEMBRANES
HYDROXY COMPOUNDS
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NUMERICAL DATA
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology