Pathophysiological and disease constraints on aerosol delivery

Technical Report · Sun Jan 01 00:00:00 EST 1989

OSTI ID:5598995

Gerrity, T R

The dose of inhaled particles to the respiratory tract depends upon many factors. These factors include the size of the particles, the pattern of breathing (flow and tidal volume), the physical properties of the articles (hygroscopic or non-hygroscopic), anatomy of the respiratory tract, and the pathophysiologic status of the respiratory tract. In addition to these factors, which are primarily related to the deposition of particles, the rate of particle clearance from the respiratory tract also influences the dose of particles. The paper is a review of the various factors influencing dose of inhaled particles to the respiratory tract. The emphasis of the paper is on therapeutic aerosol particles, though the principals discussed also apply to toxic particles as well. An important area of consideration is the influence of disease on the delivery of particle dose. From the point of view of toxic particles this is important when considering potential susceptible populations.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
• OSTI ID: 5598995
• Report Number(s): PB-89-218804/XAB; EPA-600/D-89/005
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
AEROSOLS
DOSE LIMITS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
TOXIC MATERIALS
RESPIRATION
DEPOSITION
DIFFUSION
LARYNX
LUNGS
NOSE
ORAL CAVITY
PARTICLE SIZE
PHARMACOLOGY
THERAPY
BODY
BODY AREAS
COLLOIDS
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
FACE
HEAD
MATERIALS
ORGANS
SAFETY STANDARDS
SIZE
SOLS
STANDARDS
560300* - Chemicals Metabolism & Toxicology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)