Sodium lauryl sulfate enhances nickel penetration through guinea-pig skin. Studies with energy dispersive X-ray microanalysis
The effect of sodium lauryl sulphate (SLS), a common ingredient of detergents, on the penetration of nickel through the stratum corneum in the guinea-pig skin model was studied with energy dispersive X-ray microanalysis (EDX) to evaluate the barrier-damaging properties of this common detergent. The EDX technique allows a simultaneous determination of physiologically important elements, e.g., Na, Mg, P, Cl, K, Ca and S in addition to Ni at each point of measurement in epidermal cell strata. Our results show that SLS reduces the barrier function to Ni-ion penetration of the stratum corneum. In addition we have shown that EDX allows analysis of the influence of different factors involved in nickel penetration through the skin by giving data on the physiological effects on the epidermal cells caused by the applied substances.
- Research Organization:
- Karolinska Institute, Stockholm (Sweden)
- OSTI ID:
- 5595691
- Journal Information:
- Scan. Microsc.; (United States), Vol. 3:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CELL MEMBRANES
PERMEABILITY
DETERGENTS
BIOLOGICAL EFFECTS
NICKEL
SKIN ABSORPTION
ELECTRON MICROPROBE ANALYSIS
GUINEA PIGS
SKIN
SODIUM SULFATES
X RADIATION
ABSORPTION
ADDITIVES
ALKALI METAL COMPOUNDS
ANIMALS
BODY
CELL CONSTITUENTS
CHEMICAL ANALYSIS
ELECTROMAGNETIC RADIATION
ELEMENTS
EMULSIFIERS
IONIZING RADIATIONS
MAMMALS
MEMBRANES
METALS
MICROANALYSIS
ORGANS
OXYGEN COMPOUNDS
RADIATIONS
RODENTS
SODIUM COMPOUNDS
SULFATES
SULFUR COMPOUNDS
SURFACTANTS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
WETTING AGENTS
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques