Quantification of Helicobacter pylori infection in gastritis and ulcer disease using a simple and rapid carbon-14-urea breath test

Journal Article · Sat Jun 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5594496

Debongnie, J C; Pauwels, S; Raat, A; de Meeus, Y; Haot, J; Mainguet, P ^[1]

---

1. Department of Nuclear Medicine, University of Louvain Medical School, Brussels (Belgium)

Gastric urease was studied isotopically in 230 patients with biopsy-proven normal mucosa or chronic gastritis, including 59 patients with ulcer disease. Carbon-14-urea was given in 25 ml of water without substrate carrier or nutrient-dense meal, and breath samples were collected over a 60-min period. The amount of 14CO2 excreted at 10 min was independent of the rate of gastric emptying and was not quantitatively influenced by the buccal urease activity. The 10-min 14CO2 values discriminated well between Helicobacter pylori positive and negative patients (94% sensitivity, 89% specificity) and correlated with the number of organisms assessed by histology. The test was a good predictor of chronic gastritis (95% sensitivity and 96% specificity), and a quantitative relationship was observed between 14CO2 values and the severity and activity of the gastritis. In H. pylori positive patients, breath 14CO2 was found to be similar in patients with and without ulcer disease, suggesting that the number of bacteria is not a determining factor for the onset of ulceration.

• OSTI ID: 5594496
• Journal Information: Journal of Nuclear Medicine; (United States), Vol. 32:6; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
UREASE
ENZYME ACTIVITY
BACTERIAL DISEASES
CARBON 14 COMPOUNDS
CARBON DIOXIDE
MAN
PATIENTS
ULCERS
UREA
AMIDES
AMIDINASES
ANIMALS
CARBON COMPOUNDS
CARBON OXIDES
CARBONIC ACID DERIVATIVES
CHALCOGENIDES
DISEASES
ENZYMES
HYDROLASES
INFECTIOUS DISEASES
LABELLED COMPOUNDS
MAMMALS
NON-PEPTIDE C-N HYDROLASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics