Pretreatment prognostic factors in carcinoma of the uterine cervix: a multivariable analysis of the effect of age, stage, histology and blood counts on survival

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90060-3· OSTI ID:5587280

Kapp, D S; Fischer, D; Gutierrez, E; Kohorn, E I; Schwartz, P E

From January, 1953 thorugh December, 1977, 910 previously untreated patients with invasive carcinoma of the uterine cervix (Stages IB-IVB) were seen at Yale-New Haven Medical Center and affiliated hospitals. An extensive retrospective analysis was undertaken in an attempt to identify prognostically significant pretreatment factors. The patients studied were uniformly staged according to the current FIGO recommendations and the majority of patients had been treatment under standardized protocols combining external beam radiation therapy and intracavity radium. Pretreatment parameters, including prior medical illnesses, gross tumor characteristics, histology, and blood parameters were studied, employing stepwise Cox regression analyses to identify the possible effects of all factors and all two-way interactions among fators on survival, disease-free survival and freedom from local-regional failure, controlling for stage of disease. FIGO stage patients age at diagnosis, pretreatment neutrophil count and hematocrit, uterine position, prior subtotal hysterectomy, histology, history of diabetes mellitus and number of pregnancies were all found to have prognostic significance. When other factors including stage of disease were controlled for, increased tumor size was associated with decreased disease-free survival and local-regional control rates.

• Research Organization: Yale Univ., New Haven, CT
• OSTI ID: 5587280
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOTHERAPY
EVALUATION
AGE DEPENDENCE
CARCINOMAS
EXTERNAL IRRADIATION
HISTOLOGY
MULTIVARIATE ANALYSIS
PATIENTS
RADIUM
UTERUS
ALKALINE EARTH METALS
BODY
DISEASES
ELEMENTS
FEMALE GENITALS
IRRADIATION
MATHEMATICS
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
STATISTICS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)