Cellular immune mechanisms in Coxsackievirus group B, type 3 induced myocarditis in Balb/C mice

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Adv. Exp. Med. Biol.; (United States)

DOI:https://doi.org/10.1007/978-1-4684-4472-8_29· OSTI ID:5586816

Huber, S A; Job, L P

Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.

• Research Organization: Department of Pathology, University of Vermont, Burlington
• OSTI ID: 5586816
• Journal Information: Adv. Exp. Med. Biol.; (United States), Vol. 161
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEART
VIRAL DISEASES
VIRUSES
IMMUNE REACTIONS
LYMPHOCYTES
MICE
RADIATION CHIMERAS
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASES
INFECTIOUS DISEASES
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
MOSAICISM
ORGANS
PARASITES
RODENTS
SOMATIC CELLS
VERTEBRATES
550900* - Pathology