Radiographic quantitation of reversible blood-brain barrier disruption in vivo. [Dogs]

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Radiology; (United States)

OSTI ID:5586709

Drayer, B P; Schmeckel, D E; Hedlund, L W; Lischko, M M; Sage, M R; Heinz, E R; Dubois, P J; Goulding, P L

Cranial computed tomography (CT) was used to quantitate disruption of the blood-brain barrier (BBB) in dogs in vivo following intracarotid infusion of hypertonic mannitol. The degree of opening varied with the same dose and infusion rate. The ratio of contrast enhancement in brain vs. venous blood was elevated in 4 of 5 mannitol-treated animals, with the ipsilateral basal ganglia and cortical gray matter. The statistical significance and reproducibility of the derived CT numbers used for brain and venous blood calculations, as well as the linear relationship between iodine concentration and CT enhancement, was affirmed by obtaining multiple consecutive scans.

• Research Organization: Duke Univ. Medical Center, Durham, NC
• OSTI ID: 5586709
• Journal Information: Radiology; (United States), Vol. 143:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD-BRAIN BARRIER
BIOCHEMISTRY
BRAIN
COMPUTERIZED TOMOGRAPHY
ALCOHOLS
CONTRAST MEDIA
DOGS
IMAGES
MONOSACCHARIDES
OPTIMIZATION
RESPONSE MODIFYING FACTORS
ANIMALS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DIAGNOSTIC TECHNIQUES
HYDROXY COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)