Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue. [Mice]

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90072-X· OSTI ID:5585673

Ogawa, Y; Imanaka, K; Ashida, C; Takashima, H; Imajo, Y; Kimura, S

Active specific immunotherapy using the immune reaction of a low-dose irradiated tumor tissue was studied on the transplanted MM46 tumor of female C3H/He mice after radiotherapy. MM46 tumor cells were inoculated into the right hind paws of mice. On the 5th day, irradiation with the dose irradiated tumor tissue (2000 rad on the fifth day), were injected into the left hind paws of the tumor-bearing mice. Effectiveness of this active specific immunotherapy against tumor was evaluated by the regression of tumor and survival rate of mice. Tumor was markedly regressed and survival rate was significantly increased by the active specific immunitherapy.

• Research Organization: Kobe Univ. School of Medicine, Japan
• OSTI ID: 5585673
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
IMMUNITY
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
CARCINOMAS
ELECTRON BEAMS
EXPERIMENTAL NEOPLASMS
IMMUNOTHERAPY
LOW DOSE IRRADIATION
MEV RANGE 01-10
MICE
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
DISEASES
ENERGY RANGE
IRRADIATION
LEPTON BEAMS
MAMMALS
MEDICINE
MEV RANGE
NEOPLASMS
NUCLEAR MEDICINE
PARTICLE BEAMS
RADIATION EFFECTS
RADIOLOGY
RODENTS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
550200 - Biochemistry