Enhancement of the white matter following prophylactic therapy of the central nervous system for leukemia: radiation effects and methotrexate leukoencephalopathy

Journal Article · Sat Aug 01 00:00:00 EDT 1981 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.140.2.6942436· OSTI ID:5585249

Shalen, P R; Ostrow, P T; Glass, P J

The authors report a case of fatal necrotizing leukoencephalopathy following prophylactic therapy of the central nervous system for acute lymphoblastic leukemia. The clinical, CT, and neuropathological findings are described. The CT scan demonstrated symmetrical white-matter enhancement. Histological analysis was consistent with the effects of irradiation and methotrexate. The differential diagnosis of the clinical and CT findings is discussed. Brain biopsy is the diagnostic procedure of choice.

• OSTI ID: 5585249
• Journal Information: Radiology; (United States), Vol. 140:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CENTRAL NERVOUS SYSTEM
BIOLOGICAL RADIATION EFFECTS
ENCEPHALITIS
RADIOINDUCTION
BIOPSY
BRAIN
DEATH
DIAGNOSIS
HISTOLOGY
LEUKEMIA
METHOTREXATE
PATIENTS
RADIOTHERAPY
ANTIMETABOLITES
BIOLOGICAL EFFECTS
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HEMIC DISEASES
INFECTIOUS DISEASES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
VIRAL DISEASES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man
551000 - Physiological Systems