Synthesis of catechol estrogens by human uterus and leiomyoma

Journal Article · Sun Feb 01 00:00:00 EST 1981 · Steroids; (United States)

DOI:https://doi.org/10.1016/S0039-128X(81)80017-7· OSTI ID:5584732

Reddy, V V; Hanjani, P; Rajan, R

Homogenates of human endometrial, myometrial and leiomyoma tissues were incubated with (2,4,6,7-/sub 3/H)-estradiol and tritiated catechol estrogens were isolated and identified. Though 2- and 4-hydroxylations were about the same in endometrium, 4-hydroxylation was two to four fold higher than 2-hydroxylation in myometrium and leiomyoma. However, endometrium showed greater capacity to form both 2- and 4-hydroxyestrogens than the other two tissues. Both 2- and 4-hydroxylations were significantly less than in myometrium. In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma.

• OSTI ID: 5584732
• Journal Information: Steroids; (United States), Vol. 37:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARBON ISOTOPES
ISOTOPE APPLICATIONS
ESTROGENS
BIOSYNTHESIS
TRITIUM COMPOUNDS
ANTINEOPLASTIC DRUGS
COMPARATIVE EVALUATIONS
HOMOGENATES
HYDROXYLASES
NEOPLASMS
PHYSIOLOGY
PYROCATECHOL
QUANTITATIVE CHEMICAL ANALYSIS
UTERUS
WOMEN
ANIMALS
AROMATICS
BODY
CHEMICAL ANALYSIS
DEVELOPERS
DISEASES
DRUGS
ENZYMES
FEMALE GENITALS
FEMALES
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHENOLS
POLYPHENOLS
PRIMATES
STEROID HORMONES
SYNTHESIS
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
551001 - Physiological Systems- Tracer Techniques
550901 - Pathology- Tracer Techniques