Irradiation- and cyclophosphamide-induced alterations in Syrian hamster T-cell population activity

Journal Article · Sat Feb 01 00:00:00 EST 1986 · J. Leukocyte Biol.; (United States)

OSTI ID:5584525

Bagasra, O; Tabor, D

The treatment of hamsters with either irradiation (IR) or cyclophosphamide (CYP) markedly alters select aspects of their cellular immune functions in a dose-related manner. One mechanism that may be responsible for this activity appears to be the dimunition of a T-lymphocyte subpopulation that exerts suppressive influence upon the B-lymphocyte reactivity toward antigens. This study shows that in the hamster, immune susceptibility is affected by the magnitude and orientation of these agents (ie, IR, CYP) as they temporally relate to immunization and/or challenge with the antigen. Moreover, there is evidence that T-independent as well as T-dependent responses are affected by these treatments. Therefore, cyclophosphamide and irradiation modalities can be employed to modify the cellular immune responses in the hamster.

• Research Organization: Hahnemann Univ., Philadelphia, PA
• OSTI ID: 5584525
• Journal Information: J. Leukocyte Biol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
ANTIBODY FORMATION
DOSE-RESPONSE RELATIONSHIPS
ENDOXAN
HAMSTERS
IMMUNE REACTIONS
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DRUGS
IMMUNOSUPPRESSIVE DRUGS
LEUKOCYTES
MAMMALS
MATERIALS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals