Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ. beta. chain

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.87.19.7370· OSTI ID:5584296

Dorman, J S; LaPorte, R E; Trucco, M ^[1]; Stone, R A ^[2]

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1. Graduate School of Public Health, Pittsburgh, PA (USA)
2. Univ. of Pittsburgh, PA (USA)

The presence of an amino acid other than aspartic acid at position 57 of the HLA-DQ {beta} chain (non-Asp-57) is highly associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), whereas an aspartic acid at this position (Asp-57) appears to confer resistance to the disease. The authors hypothesize that the 30-fold difference in IDDM incidence across racial groups and countries is related to variability in the frequency of these alleles. Diabetic and nondiabetic individuals were evaluated in five populations, including those at low, moderate, and high risk. HLA-DQ {beta} genotype distributions among the IDDM case groups were markedly different as were those among nondiabetic controls. Non-Asp-57 alleles were significantly associated with IDDM in all areas; population-specific odds ratios for non-Asp-57 homozygotes relative to Asp-57 homozygotes ranged from 14 to 111. Relative risk information from the case-control study and population incidence data were combined to estimate genotype-specific incidence rates for the Allegheny county, PA, Caucasians. These rates were used to predict the overall incidence rates in the remaining populations, which were within the 95% confidence intervals of the actual rates established from incidence registries. These results are consistent with the hypothesis that population variation in the distribution of non-Asp-57 alleles may explain much of the geographic variation in IDDM incidence.

• OSTI ID: 5584296
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 87:19; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
GEOGRAPHICAL VARIATIONS
HISTOCOMPATIBILITY COMPLEX
AMINO ACID SEQUENCE
ASPARTIC ACID
BIOLOGICAL MARKERS
DISEASE INCIDENCE
EPIDEMIOLOGY
GENOTYPE
HUMAN POPULATIONS
INSULIN
AMINO ACIDS
ANTIGENS
CARBOXYLIC ACIDS
DISEASES
ENDOCRINE DISEASES
HORMONES
METABOLIC DISEASES
MOLECULAR STRUCTURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
POPULATIONS
VARIATIONS
550201* - Biochemistry- Tracer Techniques