Teratologic studies of solvent-refined-coal-process materials

Conference · Thu Sep 01 00:00:00 EDT 1983

OSTI ID:5584144

Hackett, P L; Sikov, M R; Springer, D L; Mahlum, D D; Kelman, B J

The most striking effects observed following intragastric or inhalation exposure of pregnant rats to SRC materials were related to the fetal lungs: a dose-dependent decrease in weight and an increased incidence of small lungs. Whether the SRC materials was heavy distillate or a process development unit material (HPS) did not appear to influence fetal effects, but higher-boiling-range materials induced fetal responses at lower doses. The most sensitive period for production of small lungs and cleft palate was from 12 through 14 days gestation.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5584144
• Report Number(s): PNL-SA-10966; CONF-8308109-2; ON: DE84000119
• Resource Relation: Conference: 3. international congress on toxicology, San Diego, CA, USA, 28 Aug 1983
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COAL LIQUIDS
TOXICITY
EMBRYOS
CONGENITAL MALFORMATIONS
PRENATAL EXPOSURE
SOLVENT-REFINED COAL
HEALTH HAZARDS
TERATOGENS
FLUIDS
FUELS
HAZARDS
LIQUIDS
MALFORMATIONS
PATHOLOGICAL CHANGES
016000* - Coal
Lignite
& Peat- Health & Safety
560300 - Chemicals Metabolism & Toxicology