Ozone selectively inhibits growth of human cancer cells
Journal Article
·
· Science (Washington, D.C.); (United States)
The growth of human cancer cells from lung, breast, and uterine tumors was selectively inhibited in a dose-dependent manner by ozone at 0.3 to 0.8 part per million of ozone in ambient air during 8 days of culture. Human lung diploid fibroblasts served as noncancerous control cells. The presence of ozone at 0.3 to 0.5 part per million inhibited cancer cell growth 40 and 60 percent, respectively. The noncancerous lung cells were unaffected at these levels. Exposure to ozone at 0.8 part per million inhibited cancer cell growth more than 90 percent and control cell growth less than 50 percent. Evidently, the mechanisms for defense against ozone damage are impaired in human cancer cells.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5580497
- Journal Information:
- Science (Washington, D.C.); (United States), Vol. 209:4459
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
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TUMOR CELLS
INHIBITION
CELL CULTURES
DOSE-RESPONSE RELATIONSHIPS
LUNGS
MAMMARY GLANDS
PATIENTS
UTERUS
ANIMAL CELLS
BODY
FEMALE GENITALS
GLANDS
ORGANS
RESPIRATORY SYSTEM
550300* - Cytology
550600 - Medicine
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)