Antihypertensive neutral lipid

Patent · Tue Jun 17 00:00:00 EDT 1986

OSTI ID:5578512

Snyder, F L; Blank, M L

A method is described for treating a warm-blooded animal comprising administering to the animal a neutral glycerolipid with a 12 to 20 carbon alkyl group at the sn-1 position, a short carbon chain acyl group at the sn-2 position and a hydroxyl group at the sn-3 position in an amount sufficient to lower the arterial blood pressure of the animal. A method is also described for treating a warm-blooded animal comprising administering a composition consisting essentially of a 1-alkyl-2-acetyl (or propionyl)-sn glycerol in combination with a 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, wherein the 1-alkyl groups contain 12 to 20 carbon atoms, dissolved in an inert pharmaceutically acceptable solvent in amounts sufficient to lower the arterial blood pressure of the animal.

• Assignee: Dept. of Energy, Washington, DC
• Patent Number(s): US 4595681
• OSTI ID: 5578512
• Resource Relation: Patent File Date: Filed date 26 Oct 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIHYPERTENSIVE AGENTS
HYPERTENSION
THERAPY
LIPIDS
THERAPEUTIC USES
BLOOD PRESSURE
CARBON
DISSOLUTION
QUANTITY RATIO
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
ELEMENTS
NONMETALS
ORGANIC COMPOUNDS
SYMPTOMS
USES
VASCULAR DISEASES
550600* - Medicine