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Title: Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis

Abstract

The presence of hydroxyapatite has been determined based on ultrastructure, X-ray diffraction, electron diffraction, and chemical analysis, and confirmed by microprobe analysis in multiple deposits surgically excised from four unrelated patients with tumoral calcinosis. The chemical composition of each of the mineralized deposits resembled bone, rather than dermis, in mineral, uronic acid, total lipid, and complexed acidic phospholipid composition. No collagen abnormalities were detected. However, all of these deposits differed from normal bone mineral, being heavily mineralized and containing larger, more perfect hydroxyapatite crystals. Ultrastructurally, the crystals were both extracellular and within mononuclear cells in close proximity to dilated rough endoplasmic reticulum.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Department of Biochemistry, Hospital For Special Surgery, New York, New York
OSTI Identifier:
5578124
Resource Type:
Journal Article
Journal Name:
Clin. Orthop.; (United States)
Additional Journal Information:
Journal Volume: 178
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 62 RADIOLOGY AND NUCLEAR MEDICINE; CALCINOSIS; ELECTRON DIFFRACTION; ELECTRON MICROPROBE ANALYSIS; X-RAY DIFFRACTION; NEOPLASMS; ADOLESCENTS; COLLAGEN; FEMALES; LIPIDS; PATIENTS; PHOSPHOLIPIDS; URONIC ACIDS; AGE GROUPS; CARBOXYLIC ACIDS; CHEMICAL ANALYSIS; COHERENT SCATTERING; DIFFRACTION; DISEASES; ESTERS; MICROANALYSIS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PATHOLOGICAL CHANGES; PROTEINS; SCATTERING; SCLEROPROTEINS; 550900* - Pathology; 550602 - Medicine- External Radiation in Diagnostics- (1980-)

Citation Formats

Boskey, A L, Vigorita, V J, Sencer, O, Stuchin, S A, and Lane, J M. Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis. United States: N. p., 1983. Web. doi:10.1097/00003086-198309000-00036.
Boskey, A L, Vigorita, V J, Sencer, O, Stuchin, S A, & Lane, J M. Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis. United States. https://doi.org/10.1097/00003086-198309000-00036
Boskey, A L, Vigorita, V J, Sencer, O, Stuchin, S A, and Lane, J M. 1983. "Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis". United States. https://doi.org/10.1097/00003086-198309000-00036.
@article{osti_5578124,
title = {Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis},
author = {Boskey, A L and Vigorita, V J and Sencer, O and Stuchin, S A and Lane, J M},
abstractNote = {The presence of hydroxyapatite has been determined based on ultrastructure, X-ray diffraction, electron diffraction, and chemical analysis, and confirmed by microprobe analysis in multiple deposits surgically excised from four unrelated patients with tumoral calcinosis. The chemical composition of each of the mineralized deposits resembled bone, rather than dermis, in mineral, uronic acid, total lipid, and complexed acidic phospholipid composition. No collagen abnormalities were detected. However, all of these deposits differed from normal bone mineral, being heavily mineralized and containing larger, more perfect hydroxyapatite crystals. Ultrastructurally, the crystals were both extracellular and within mononuclear cells in close proximity to dilated rough endoplasmic reticulum.},
doi = {10.1097/00003086-198309000-00036},
url = {https://www.osti.gov/biblio/5578124}, journal = {Clin. Orthop.; (United States)},
number = ,
volume = 178,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 1983},
month = {Thu Sep 01 00:00:00 EDT 1983}
}