/sup 14/C-lactose breath tests during pelvic radiotherapy: the effect of the amount of small bowel irradiated
Thirty patients who were undergoing pelvic radiotherapy had /sup 14/C-lactose breath tests performed in the first and fifth weeks of treatment. In Group I (21 patients), a significant portion of the small intestine was irradiated, and in Group II (9 patients), only a small portion of the small intestine was irradiated. In Group I, the average reductions in the excretion of ingested /sup 14/C between the first- and fifth-week tests were 41.5% at 1/2 hour postingestion (p<0.05), and 21.8% at 1 hour postingestion (p<0.05). In Group II, the prercentage reduction were 11.8% and 3.7% at 1/2 and 1 hour, respectively (p>0.05). The data suggest that lactose malabsorption is a factor in the etiology of the nausea, vomiting, and diarrhea experienced by patients who are undergoing pelvic radiotherapy, and that the amount of bowel included in the treatment volume significantly influences the degree of malabsorption.
- Research Organization:
- M.S. Hershey Medical Center, Hershey, PA
- OSTI ID:
- 5576863
- Journal Information:
- Radiology; (United States), Vol. 142:2
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
LACTOSE
INTESTINAL ABSORPTION
PATIENTS
RADIATION SYNDROME
RADIOTHERAPY
SIDE EFFECTS
SMALL INTESTINE
BIOLOGICAL RADIATION EFFECTS
CARBON 14 COMPOUNDS
NEOPLASMS
PARTIAL BODY IRRADIATION
ABSORPTION
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
DIGESTIVE SYSTEM
DISACCHARIDES
DISEASES
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
INTESTINES
IRRADIATION
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOLOGY
SACCHARIDES
THERAPY
UPTAKE
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics