Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function
BALB/c mice treated with total lymphoid irradiation (TLI) develop non-antigen-specific suppressor cells of the adoptive secondary antibody response and of the mixed leukocyte reaction. Suppressors of the adoptive anti-DNP response were eliminated by incubation of spleen cells with anti-Thy-1.2 or anti-thymus-leukemia (TL) antiserum and complement before cell transfer. Thymectomy before TLI prevented the appearance of the latter suppressor cells. On the other hand, suppressors of the MLR were eliminated by incubation of spleen cells with anti-Thy-1.2 but not anti-TL antiserum and complement. Thymectomy before TLI did not prevent their subsequent development. Thus, two subpopulations of suppressor T cells that differ in the expression of the TL surface antigen, dependence on the presence of the thymus, and in regulatory functions develop after TLI. The TL+, thymus-dependent cell suppresses the adoptive antibody response, and the TL-, thymus-independent cell suppresses the MLR.
- OSTI ID:
- 5576395
- Journal Information:
- J. Exp. Med.; (United States), Vol. 154:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMMUNOSUPPRESSION
RADIOINDUCTION
LYMPHOCYTES
BIOLOGICAL RADIATION EFFECTS
THYMECTOMY
RADIOSENSITIVITY EFFECTS
ANTIGENS
LYMPH NODES
MICE
PARTIAL BODY IRRADIATION
SPLEEN CELLS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MEDICINE
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
SURGERY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals