Neuronal damage in chick and rat embryos following X-irradiation

Journal Article · Mon Dec 01 00:00:00 EST 1980 · Teratology; (United States)

DOI:https://doi.org/10.1002/tera.1420220307· OSTI ID:5576191

Schneider, B F; Norton, S

Exposure of rat and chick embryos to X-irradiation at the time of development of neurons at the telencephalic-diencephalic border results in prolonged damage to neurons in this area as measured by neuronal nuclear size. A dose of 100 rads to the seven-day-old chick embryo has about the same effect as 125 rads to the 15-day-old rat fetus. The nuclear volume of large, multipolar neurons in the chick paleostriatum primitivum and the rat lateral preoptic area are reduced from 10 to 15%. Larger doses of X-irradiation to the chick (150 and 200 rads) cause progressively greater reductions in nuclear size. The large neurons which were measured in the rat and chick are morphologically similar in the two species. Both contain cytoplasmic acetylcholinesterase and have several branched, spiny dendritic processes. The similarity of response of chick and rat neurons to X-irradiation diminishes the significance of maternal factors as the cause of the effects of fetal irradiation in these experiments.

• OSTI ID: 5576191
• Journal Information: Teratology; (United States), Vol. 22:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
NERVE CELLS
BIOLOGICAL RADIATION EFFECTS
CHICKENS
DOSE-RESPONSE RELATIONSHIPS
EMBRYOS
MORPHOLOGY
RADIATION DOSES
RATS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
DOSES
ELECTROMAGNETIC RADIATION
FOWL
IONIZING RADIATIONS
MAMMALS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550300 - Cytology