cap alpha. /sub 2/-Adrenergic receptors in platelet membranes of depressed patients: no change in number of /sup 3/H-yohimbine affinity

Journal Article · Mon Nov 16 00:00:00 EST 1981 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(81)90662-7· OSTI ID:5574664

Daiguji, M I ^[1]; Meltzer, H Y; Tong, C; U'Pritchard, D C; Young, M; Kravitz, H

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1. Pritzber School of Medicine, Chicago

The ..cap alpha../sub 2/-adrenergic receptor density in platelet membranes from normal controls and depressed patients was studied using /sup 3/H-yohimbine, a potent ..cap alpha../sub 2/-adrenergic antagonist, as a radioligand. The KD values of /sup 3/H-yohimbine in control and depressed patient samples were 0.92 +/- 0.07 nM and 0.97 +/- 0.06 nM, respectively. The Bmax values of controls and depressed patients were 240 +/- 19 fmoles/mg protein (125 +/- 13 receptor/platelet, R/PL) and 204 +/- 20 fmoles/mg protein (130 +/- 14 R/PL), respectively. There were no significant differences between the KD and Bmax values of the two groups.

• OSTI ID: 5574664
• Journal Information: Life Sci.; (United States), Vol. 29:20
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
SYMPATHOLYTICS
BIOCHEMISTRY
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
UPTAKE
ANTIDEPRESSANTS
BLOOD PLATELETS
EXPERIMENTAL DATA
LIGANDS
MENTAL DISORDERS
PATIENTS
RECEPTORS
TRACER TECHNIQUES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
CHEMISTRY
DATA
DRUGS
INFORMATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
NUMERICAL DATA
PSYCHOTROPIC DRUGS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550101 - Behavioral Biology- Tracer Techniques