Calmodulin inhibition: a possible predictor of metal-ion toxicity

Conference · Wed Jan 01 00:00:00 EST 1986

OSTI ID:5574590

Williams, M W; Turner, J E; Hsie, A W

A correlation between CE/sub 50/, the metal-ion concentration which reduces the cloning efficiency of CHO cells by 50%, and IC/sub 50/, the metal-ion concentration that produces an inhibition of calmodulin activity of 50%, is reported for 10 divalent metal ions. It is thus suggested that IC/sub 50/ might be used as a predictor of metal-ion toxicity in CHO cells. Arguments are presented to support the extrapolation of these results to other pollutants and to other biological species.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5574590
• Report Number(s): CONF-8606163-1; ON: DE86013266
• Resource Relation: Conference: 2. international workshop on QSAR in environmental toxicology, Hamilton, Ontario, Canada, 9 Jun 1986; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENZYME ACTIVITY
INHIBITION
METALS
TOXICITY
BERYLLIUM
CADMIUM
CATIONS
CHO CELLS
COBALT
COPPER
CORRELATIONS
ENZYME INHIBITORS
MANGANESE
MERCURY
NICKEL
PALLADIUM
STRONTIUM
ZINC
ALKALINE EARTH METALS
ANIMAL CELLS
CHARGED PARTICLES
ELEMENTS
IONS
PLATINUM METALS
TRANSITION ELEMENTS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)