Investigation of protein binding of radiogallium. Progress report
Technical Report
·
OSTI ID:5569126
The main objective of the contract is to study aspects of the localization of gallium-67 in tumor are reported and compared with a new tumor imaging agent, specifically radiolabeled monoclonal tumor antibody. Our studies have demonstrated that phosphate compounds used in bone imaging do not significantly influence gallium-67 localization, that the adenosine triphosphate cannot be used to enhance gallium-67 uptake in malignant tissue, and that gallium-67 has higher affinity than radiolabeled anti-p97 for melanoma, even in tumors which produce significant amounts of p97 antigen on their cell surface. 23 refs., 17 figs., 5 tabs.
- Research Organization:
- Yale Univ., New Haven, CT (USA)
- DOE Contract Number:
- AC02-78EV04625
- OSTI ID:
- 5569126
- Report Number(s):
- DOE/EV/04625-T4; ON: DE85015578
- Country of Publication:
- United States
- Language:
- English
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Evaluation of energy spectral information in nuclear imaging and investigation of protein binding of radiogallium. Progress report, October 1, 1980-November 30, 1983
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OSTI ID:5569126
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GALLIUM 67
TISSUE DISTRIBUTION
INDIUM 111
MONOCLONAL ANTIBODIES
ATP
BLOOD
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
HEART
ION EXCHANGE CHROMATOGRAPHY
LIVER
LUNGS
MELANOMAS
MICE
MUSCLES
SKELETON
SKIN
SPLEEN
THIN-LAYER CHROMATOGRAPHY
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLANDS
INDIUM ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GALLIUM 67
TISSUE DISTRIBUTION
INDIUM 111
MONOCLONAL ANTIBODIES
ATP
BLOOD
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
HEART
ION EXCHANGE CHROMATOGRAPHY
LIVER
LUNGS
MELANOMAS
MICE
MUSCLES
SKELETON
SKIN
SPLEEN
THIN-LAYER CHROMATOGRAPHY
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CHROMATOGRAPHY
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLANDS
INDIUM ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
NUCLEOTIDES
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)