Neurotransmitter mechanisms of the action of the antihistamine dimebon on the brain
To discover the possible mechanism of the stimulating effect of dimebon on the CNS, the action of the drug was studied on catecholamine concentrations and turnover and activity of forms of monoamine oxidase (MAO), differing in the substrate metabolized, in brain structures involved in the regulation of the emotional state and in the regulation of motor activity in rats. /sup 3/H-serotonin creatinine-sulfate, /sup 3/H-dopamine hydrochloride, and /sup 14/C- benzylamine hydrochloride were used as substrates. The results show that dimebon can inhibit MAO activity in the basal ganglia and other brain structures both in vitro and in vivo, and can cause changes in DA and NA metabolism and in functional activity of catecholaminergic neuronal structures of the brain.
- Research Organization:
- Minsk Medical Institute, USSR
- OSTI ID:
- 5563318
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:6; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 6, 700-702(Jun 1986)
- Country of Publication:
- United States
- Language:
- English
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ANTIHISTAMINICS
BIOLOGICAL EFFECTS
BRAIN
BIOCHEMISTRY
CATECHOLAMINES
METABOLISM
OXIDOREDUCTASES
ENZYME ACTIVITY
RADIOENZYMATIC ASSAY
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
HISTAMINE
INHIBITION
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RATS
RECEPTORS
SEROTONIN
SUBSTRATES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DRUGS
ENZYMES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
INDOLES
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SYMPATHOMIMETICS
TRYPTAMINES
VERTEBRATES
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