Influence of 5-hydroxytryptamine (serotonin) on blood flow in the dog pulp

Journal Article · Thu May 01 00:00:00 EDT 1986 · J. Dent. Res.; (United States)

DOI:https://doi.org/10.1177/00220345860650051001· OSTI ID:5562900

Kim, S; Trowbridge, H O; Dorscher-Kim, J E

The effect of intra-arterial injection of 5-hydroxytryptamine (5-HT) on pulpal blood flow of the dog was determined using the 15-micron radioisotope-labeled microsphere injection method. Pulpal blood flow was significantly reduced following the 5-HT injection. This decrease in blood flow appeared to be due to vasoconstriction as determined by an increase in pulpal vascular hindrance. However, our findings do not preclude the possibility that blood flow was reduced as a result of passive compression of venules produced by vasodilation in a low-compliance environment.

• Research Organization: Columbia Univ., New York, NY
• OSTI ID: 5562900
• Journal Information: J. Dent. Res.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SEROTONIN
BIOLOGICAL EFFECTS
TEETH
BLOOD FLOW
DENTISTRY
DOGS
MICROSPHERES
RADIOISOTOPES
SCANDIUM
VASOCONSTRICTION
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPES
MAMMALS
MEDICINE
METALS
NEUROREGULATORS
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRANSITION ELEMENTS
TRYPTAMINES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques