Polymorphism in a second ABC transproter gene located within the class II region of the human major histocompatibility complex

Journal Article · Sat Feb 15 00:00:00 EST 1992 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.89.4.1463· OSTI ID:5560512

Powis, S H; Mockridge, I; Kelly, A; Glynne, R; Beck, S; Trowsdale, J ^[1]; Kerr, L A ^[2]; Gileadi, U ^[3]

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1. Imperial Cancer Research Fund Labs., London (United Kingdom)
2. Guy's Campus, London (United Kingdom)
3. Univ. of Oxford (United Kingdom)

Recent studies have identified genes within the major histocompatibility complex (MHC) that may play a role in presentation of antigenic peptides to T cells. The authors have previously described RING4, a gene within the human MHC class II region that has sequence homology with members of the ABC (ATP-binding cassette) transporter superfamily. They now report the nucleotide sequence of RING11, a second ABC transporter gene located approximately 7 kilobases telomeric to RING4. RING11 is {gamma}-interferon inducible, a property shared with other genes involved in antigen presentation. Comparison between the amino acid sequences of RING11 and RING4 reveals strong homology. They propose that they form a heterodimer that transports peptides from the cytoplasm into the endoplasmic reticulum. They have identified two RING11 alleles, which differ in length of their derived protein sequence by 17 amino acids. The more common of these alleles is present in a Caucasoid population at a frequency of 79%.

• OSTI ID: 5560512
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 89:4; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HISTOCOMPATIBILITY COMPLEX
RFLPS
PEPTIDES
MEMBRANE TRANSPORT
RECOMBINANT DNA
DNA SEQUENCING
AMINO ACID SEQUENCE
ANTIGENS
ENDOPLASMIC RETICULUM
HUMAN POPULATIONS
CELL CONSTITUENTS
DNA
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550200* - Biochemistry