Pharmacokinetics in risk assessment: drinking water and health. Volume 8
Contents include: risk assessment: historical perspectives; tissue dosimetry in risk assessment; modeling: an introduction; physiologically based pharmacokinetic modeling; allometry: body-size constraints in animal design; prediction of in vivo parameters of drug metabolism and distribution from in-vitro studies; dose, species, and route extrapolation; uncertainty in pharmacokinetic models using SIMUSOLV; interspecies and dose-route extrapolations; carcinogen DNA adducts as a measure of biological dose for risk analysis of carcinogenic data; resources available for simulation in toxicology; route-to-route extrapolation of dichloromethane exposure using a physiological pharmacokinetic model; sensitivity analysis in pharmacokinetic modeling; mutation accumulation: chronic cytotoxicant exposure; model for ethylene chloride and its application in risk assessment; mathematical modeling of ozone absorption in the lower respiratory tract; development of a physiologically based pharmacokinetic model for multiday inhalation of carbon tetrachloride; the delivered/administered dose relationship and its impact on formaldehyde risk estimates; pharmacokinetic simulation in risk assessment; hazard assessment: ozone; role of pharmacokinetic modeling in risk assessment; development of multispecies, multiroute pharmacokinetic models for methylene chloride and 1,1,1-trichloroethane (methyl chloroform); methotrexate: pharmacokinetics and assessment of toxicity; prospective predictions and validations in anticancer therapy; the application of pharmacokinetic data in carcinogenic risk assessment.
- Research Organization:
- National Research Council, Washington, DC (USA)
- OSTI ID:
- 5559168
- Report Number(s):
- PB-89-203319/XAB; ISBN: 0-309-03775-1
- Resource Relation:
- Other Information: See also Volume 4, PB--82-249244. Errata sheet inserted. Library of Congress catalog card no. 77-89284
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARCINOGENS
RISK ASSESSMENT
DRINKING WATER
TOXIC MATERIALS
PHARMACOLOGY
DOSE-RESPONSE RELATIONSHIPS
EPIDEMIOLOGY
MATHEMATICAL MODELS
MEETINGS
TOXICITY
WATER TREATMENT
HYDROGEN COMPOUNDS
MATERIALS
OXYGEN COMPOUNDS
WATER
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology