Blood pressure and blood lead concentration in San Francisco MUNI bus drivers

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:5559129

Sharp, D S

San Francisco MUNI bus drivers have an increased prevalence of hypertension. This study examined relationships between blood lead concentration (Pb-B) and blood pressure (BP) in 342 drivers. Two groups of subjects were identified. These subjects treated for hypertension (n = 54) and untreated subjects (n = 288). Systolic and diastolic BPs varied from 102-173 mmHg and from 61-105 mm Hg respectively in untreated subjects. They varied from 110-206 mmHg and from 73-127 mmHg respectively in treated subjects. The Pb-B varied from 2-15 {mu}g/dl in untreated subjects, and 2-25 {mu}g/dl in treated drivers. The relationship between BP and the logarithm of Pb-B was examined in each group separately using multiple regression techniques. Covariates included age, body mass index, sex, race, and caffeine intake. The regression coefficient relating systolic BP and In(Pb-B) was 1-2 mmHg/ln({mu}g/Dl) (90% C.I.: {minus}2,5) in untreated subjects. The relationship in treated subjects was too unstable to be accurately determined. The coefficients for diastolic BP were 2.0-2.5 mmHg/ln({mu}g/dl) (90% C.I.: 0.1,4.5) and 6 mmHg/ln({mu}g/dl) (90% C.I.: 2,11) in untreated and treated subjects respectively.

• Research Organization: California Univ., Berkeley, CA (USA)
• OSTI ID: 5559129
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
BUSES
EXHAUST GASES
HYPERTENSION
EPIDEMIOLOGY
LEAD
TOXICITY
BIOLOGICAL ACCUMULATION
BLOOD PRESSURE
CALIFORNIA
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
CARDIOVASCULAR DISEASES
DISEASES
ELEMENTS
FEDERAL REGION IX
FLUIDS
GASEOUS WASTES
GASES
METALS
NORTH AMERICA
SYMPTOMS
TRANSPORTATION SYSTEMS
USA
VASCULAR DISEASES
VEHICLES
WASTES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology