Non-Hodgkin's lymphomas of head and neck extranodal sites
The initial staging, therapy and course of 156 patients with non-Hodgkin's lymphomas of head and neck extranodal sites were analyzed to determine whether they have a natural history which differs from primary nodal disease. The sites involved were: Waldeyer's ring - 103 patients (tonsil - 60, nasopharynx - 25, base of tongue -18), and extralymphatic sites - 53 patients (salivary gland - 20, paranasal sinus - 20, oral cavity - 10, and larynx - 3). Seventy-six percent had unfavorable histologies and 24% had favorable histologies. Fifty-three percent had pathologic Stages I-II and 47% had Stages III-IV. The 5-year survival was influenced by primary sites. The 5-year survival was also influenced by histology: unfavorable histologies - 39%, favorable histologies - 69%. The Ann Arbor staging system was more useful than TNM for determining outcome. For patients with Stage I-II unfavorable histologies treated with radiation alone, the 5-year surival was: involved field - 24%, extended field - 42%, total lymphoid irradiation - 52%. The majority of patients who failed did so in extranodal sites. Forty-one patients with advanced disease received a variety of chemotherapy regimens as the sole treatment. For head and neck extranodal lymphomas, limited radiation is inadequate, and combined modality programs should be considered.
- Research Organization:
- Stanford Univ. School of Medicine, CA
- OSTI ID:
- 5555670
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:2
- Country of Publication:
- United States
- Language:
- English
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550603* - Medicine- External Radiation in Therapy- (1980-)