Long-term in vivo carcinogenicity test of potassium bromate, sodium hypochlorite, and sodium chlorite conducted in Japan

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8669221· OSTI ID:5554892

Kurokawa, Y; Takayama, S; Konishi, Y; Hiasa, Y; Asahina, S; Takahashi, M; Maekawa, A; Hayashi, Y

Long-term in vivo carcinogenicity tests of potassium bromate (KBrO/sub 3/), sodium hypochlorite (NaClO) and sodium chlorite (NaClO/sub 2/) have been conducted in Japan from 1977 to 1985. In these investigations, groups of approximately 50 male and 50 female F344 rats or B6C3F1 mice were given solutions of the compounds as their drinking water ad libitum at two dose levels determined on the basis of preliminary 13-weeks tests. The carcinogenic potential of KBrO/sub 3/ was tested by administering doses of 500 or 250 ppm to rats for 110 weeks. Significantly elevated incidences of renal cell tumors in males and females and mesotheliomas of the peritoneum in males as compared to controls were observed. When female mice were given KBrO/sub 3/ at doses of 1000 or 500 ppm for 78 weeks, no significant differences in tumor incidences between experimental and control groups were apparent. The incidences of tumors in NaClO-treated and control animals of both sexes were not significantly different in both rat and mouse studies. No statistically significant differences were observed in the incidences of tumor formation between NaClO/sub 2/-treated and control groups of rats male mice, the combined incidences of hyperplastic nodules and hepatocellular carcinomas of the liver in a low-dose group, and adenomas and adenocarcinomas of the lung in a high-dose group, were marginally increased compared to controls. The authors concluded that KBrO/sub 2/ was carcinogenic in rats of both sexes. NaClO was not carcinogenic in either rats and or mice under the conditions of the present studies. Although NaClO/sub 2/ was shown to be noncarcinogenic in rats, the results for mice were evaluated as inconclusive. Also the results of two-stage mouse skin carcinogenesis using KBrO/sub 3/, NaClO, and NaClO/sub 2/ are presented.

• Research Organization: National Institute of Hygienic Sciences, Tokyo, Japan
• OSTI ID: 5554892
• Journal Information: Environ. Health Perspect.; (United States), Vol. 69
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BROMATES
BIOLOGICAL EFFECTS
CHLORINE COMPOUNDS
KIDNEYS
PATHOLOGICAL CHANGES
LIVER
LUNGS
ADENOMAS
CARCINOGENESIS
CARCINOMAS
DRINKING WATER
HISTOLOGY
HYPOCHLOROUS ACID
IN VIVO
JAPAN
MICE
NEOPLASMS
OXIDATION
POTASSIUM COMPOUNDS
RATS
SKIN
SODIUM COMPOUNDS
TUMOR PROMOTERS
ALKALI METAL COMPOUNDS
ANIMALS
ASIA
BODY
BROMINE COMPOUNDS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DISEASES
GLANDS
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
MAMMALS
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PROMOTERS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology