Radiation induced heart disease in hypertensive rats
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Spontaneously hypertensive Wistar rats were given single doses of X rays to their heart. Irradiation decreased the blood pressure before any myocardial radiation damage was apparent. Male rats, which were more hypertensive than female rats, had a shorter survival time after local heart irradiation than female rats. Antihypertensive treatment with hydralazine did not increase the survival time. It is considered that myocardial hypertrophy is the cause of the increased susceptibility of spontaneously hypertensive rats to local heart irradiation.
- Research Organization:
- Institut fur Strahlenbiologie der GSF, Neuherberg, Germany, F.R.
- OSTI ID:
- 5553704
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 14:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARDIOVASCULAR DISEASES
RADIOINDUCTION
HEART
BIOLOGICAL RADIATION EFFECTS
ACUTE IRRADIATION
BLOOD PRESSURE
DOSE-RESPONSE RELATIONSHIPS
HYPERTENSION
MYOCARDIUM
RATS
SEX DEPENDENCE
X RADIATION
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MUSCLES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
CARDIOVASCULAR DISEASES
RADIOINDUCTION
HEART
BIOLOGICAL RADIATION EFFECTS
ACUTE IRRADIATION
BLOOD PRESSURE
DOSE-RESPONSE RELATIONSHIPS
HYPERTENSION
MYOCARDIUM
RATS
SEX DEPENDENCE
X RADIATION
ACUTE EXPOSURE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MUSCLES
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals