Toxicological significance of dihydrodiol metabolites
Dihydrodiols are often found as the major organic-extractable metabolites of various olefinic or aromatic xenobiotics in many biological samples. Studies on the chemistry of dihydrodiol metabolites have provided insight into the pharmacokinetic behavior and the mode of action of the parent compound. The toxicology of dihydrodiol is more complex than what can be deduced solely on the basis of diminished bioavailability of the epoxide precursor, and the increased hydrophilicity associated with the dihydrodiol moiety. Dihydrodiols can be intrinsically toxic and may even represent metabolically activated species. Some of the dihydrodiol metabolites may still retain sufficient lipophilic character to serve again as substrates for microsomal oxygenases. Because of the tremendous chemical and biological diversity that existed among the various dihydrodiols, more mechanistic studies are needed to examine the toxicological properties of these compounds. It may be premature to conclude dihydrodiol formation as purely a detoxification route for xenobioties.
- Research Organization:
- Department of Entomology, University of Wisconsin, Madison
- OSTI ID:
- 5551676
- Journal Information:
- J. Toxicol., Clin. Toxicol.; (United States), Vol. 19:6-7
- Country of Publication:
- United States
- Language:
- English
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ALKENES
METABOLISM
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TOXICITY
GLYCOLS
METABOLIC ACTIVATION
METABOLITES
REACTION INTERMEDIATES
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HYDROCARBONS
HYDROXY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
560300* - Chemicals Metabolism & Toxicology